منابع مشابه
Mechanisms of Asymmetric Stem Cell Division
Stem cells self-renew but also give rise to daughter cells that are committed to lineage-specific differentiation. To achieve this remarkable task, they can undergo an intrinsically asymmetric cell division whereby they segregate cell fate determinants into only one of the two daughter cells. Alternatively, they can orient their division plane so that only one of the two daughter cells maintain...
متن کاملThe control of cell division; a review. I. General mechanisms.
order into a subject that has not been much dis cussed in the past.1 The amount of relevant work is considerable, and it is spread over most of cell biology. In consequence, it is quite certain that I shall have failed to notice many important papers, particularly in those subjects with which I am unfamiliar. I should be glad to hear of these omis sions. I must also apologize to the numerous au...
متن کاملAsymmetric centrosome behavior and the mechanisms of stem cell division
The ability of dividing cells to produce daughters with different fates is an important developmental mechanism conserved from bacteria to fungi, plants, and metazoan animals. Asymmetric outcomes of a cell division can be specified by two general mechanisms: asymmetric segregation of intrinsic fate determinants or asymmetric placement of daughter cells into microenvironments that provide extrin...
متن کاملDissecting the mechanisms of Notch induced hyperplasia
The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used ge...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2019
ISSN: 0021-9258
DOI: 10.1074/jbc.aw119.008149